Claudia Maier in front of black backdrop

Claudia S. Maier

Professor

Department of Chemistry

Claudia S. Maier

Professor

Department of Chemistry

Research

We focus on mass spectrometry to study biomolecules, their interactions and dynamics in relation to their biological functions. We develop analytical strategies to study the response of biological systems to exposure, stress and disease. Specifically, we explore the metabolome and proteome as comprehensive collections of molecular messengers of cellular response. For this purpose we combine chemistry, separation technologies and mass spectrometry to detect, identify and quantify biomolecules in biological systems. Current research includes 1. Gas phase and fragment ion chemistry, structure elucidation; 2. Analytical method development and quantitative mass spectrometry for applications in the environmental, plant and biomedical sciences; 3. Analytical metabolomics with focus on metabolite profiling using ion mobility mass spectrometry for biomarker discovery; 4. Proteomics techniques for studying oxidative and electrophile stress, redox signaling and homeostasis, chronic diseases and aging; 5. Mass spectrometry-enabled protein conformational and interaction analysis with emphasis on H/D exchange mass spectrometry.

Finding the "Goods" in a Molecular Jungle

The overarching problems that we try to address are 1) how do we define the molecular signatures of a biological system in response to stress caused by the environment, chronic diseases and aging? and 2) how can we manipulate the stress response to do good to the biological system?

For this purpose we combine chemistry, separation technologies and mass spectrometry to detect, identify and quantify biomolecules in complex matrices. We develop analytical methods to explore the metabolome and proteome as comprehensive collections of molecular messengers of cellular response. We have collaborations with clincial research groups in the area of disease biomarkers.

Biomolecular Mass Spectrometry

We develop and apply methods based on ion mobility mass spectrometry for the characterization of small molecules and biopolymers. We use ion mobility mass spectrometry as orthogonal method for the analysis of small molecules in complex matrices and biological systems.

Analytical Metabolomics

We develop and apply biomolecular mass spectrometry method for detecting and identifying metabolites and xenobiotics in complex biological matrices. Our methods enable us to determine the response of the metabolome to disease, host-environment interactions, and exposure in order to better define the metabolic pathways and biological networks affected by the perturbation with the goal to discvery biomarkers and guide intervention strategies.

Mass Spectrometry-based Proteomics and PTM mapping

We use a combination of biochemical methods, analytical chemistry and mass-spectrometry-based proteomics to understand dysregulation in disease and environmental exposure. We develop proteomics methods to understand the mechansims of aging, hypoxic stress in cancer and the consequence of radiation.

Ion mobility-enhanced MS(E)-based label-free analysis reveals effects the low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome. Huang et al. J. Proteomics 2016

Label-free proteomics assisted by affinity enrichment for elucidating the chemical reactivity of the liver mitochondrial proteome toward adduction by the lipid electrophile 4-hydroxy-2-nonenal (HNE). Tzeng & Maier, Front Chem. 2016

Protein modification by electrophilic lipoxidation products; adduct formation, chemical strategies and tandem mass spectrometry for their detectioan and identification. Vasil'ev YV, Tzeng SC, Huang L, Maier CS. Mass Spectrometry Rev. 2014.

We study the proteome response to changes in redox homeostasis with relevance to environmental exposure, chronic diseases and aging.

For this purpose we develop and advance analytical proteomic techniques for defining the chemical diversity of insult by oixidative and electrophile stress. We use chemoselective methods coupled to mass spectrometry to define the chemical signatures of oxidative stress at the systems level which the goal to use oxidative signatures one day for diagnosis of health status in personalized medicine and therapy monitoring.

Structural Proteomics

We study how proteins work and interact under conditions mimicking their biological environments. We study protein mobility and interactions by solution-phase hydrogen/deuterium exchange mass spectrometry (HDX-MS).

Education

Postdoctoral Fellow (1999) Oregon State University

Ph.D. (1994) University of Konstanz, Germany

Research areas

Analytical Chemistry

Publications

Tandem mass spectrometric characterization of thiol peptides modified by the chemoselective cationic sulfhydryl reagent (4-iodobutyl)triphenylphosphonium--effects of a cationic thiol derivatization on peptide fragmentation. J. Am. Soc. Mass Spectrom. 2011, 22(10):1771-83
Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction. J. Proteomics. 2011, 74(11):2417-29.
Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Nirudodhi S, Parsonage D, Karplus PA, Poole LB, Maier CS. Int. J. Mass Spectrom. 2011, 302(1-3):93-100.
Mass spectrometry-based quantification of myocardial protein adducts with acrolein in an in vivo model of oxidative stress. Mol. Nutr. Food Res. 2011 55(9):1401-10
A targeted mass spectrometry-based approach for the identification and characterization of proteins containing α-aminoadipic and γ-glutamic semialdehyde residues. Anal. Bioanal. Chem. 2010, 398(7-8):2905-14.

Protein adducts of aldehydic lipid peroxidation products identification and characterization of protein adducts using an aldehyde/keto-reactive probe in combination with mass spectrometry. Maier CS, Chavez J, Wang J, Wu J. Methods Enzymol. 2010; 473:305-30.

Zhang, Y.H., Yan, X., Maier, C.S., Schimerlik, M.I. and Deinzer, M.L. (2002) Conformational analysis of intermediates involved in the in vitro folding pathways of recombinant human macrophage colony stimulating factor beta by sulfhydryl group trapping and hydrogen deuterium (H/D) pulsed labeling, Biochemistry, 41, 15495-15504. (original research article)

Zhang, Y.H., Yan, X., Maier, C.S., Schimerlik, M.I. and Deinzer, M.L. (2001) Structural comparison of recombinant human Macrophage Colony Stimulating Factor β (rhm-CSFβ) and a partially reduced derivative using hydrogen/deuterium exchange and electrospray ionization mass spectrometry, Protein Science, 10, 2336-2345. (original research article)

Zhang , L., Vogel, W. K., Liu, X., Topark-Ngarm, A., Arbogast, B. L., Maier, C. S., Filtz, T. M., Leid M. (2012) Coordinate Regulation of Bcl11b Activity in Thymocytes by the MAPK Pathways and Protein Sumoylation. J. Biol. Chem. 287(32):26971-88 (original research article).

Zandkarimi, F., Wickramasekara, S., Morre, J., Stevens J. F. and Maier*, C. S. (201x) Electrospray ionization traveling wave ion mobility mass spectrometry for the analysis of plant phenolics: An approach for separation of regioisomers. Recent Advances in Phytochemistry, in press. (book chapter, invited contribution)

Yury V. Vasil’ev, Shin-Chen Tzeng, Lin Huang, and Claudia S. Maier* (201x) Protein modifications by electrophilic lipoxidation products: Adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification. Mass Spectrometry Reviews, 201x, in press (review invited contribution,).

Yoder, J.D., Chen, T.S., Gagnier, C.R, Vemulapalli, S., Maier, C.S., and Hruby, D.E. (2006) Pox proteomics: mass spectrometric analysis and identification of Vaccinia virion proteins. Virology Journal, 3:10, 1-16. (original research article)

Yan, X. and Maier, C.S.* (2009) Hydrogen/Deuterium Exchange Mass Spectrometry in “Methods in Molecular Biology”, 492, 255-71 (review; invited contribution).

Weinmann, W., Parker, C.E., Baumeister, K., Maier, C., Tomer, K.B. and Pryzbylski, M. (1994). Capillary electrophoresis combined with 252Cf-plasma desorption and electrospray mass spectrometry for the structural characterization of hydrophobic polypeptides using organic solvents. Electrophoresis 15, 228. (original research article)

Weinmann, W., Parker, C.E., Baumeister, K., Maier, C., Tomer, K.B. and Przybylski, M. (1994). Isolation of hydrophobic lipoproteins in organic solvents by hydrostatic-flow assisted capillary electrophoresis for subsequent mass spectrometric characterization. J. Chromatogr. A664, 271-275. (original research article)

Weinmann, W., Maier, C., and Przybylski, M. (1992). Characterization of primary structure and microheterogeneity of fatty acid-acylated lipoproteins by 252Cf-plasma desorption and electrospray mass spectrometry. Fres. Z. Anal. Chem. 343, 63. (original research article)

Voss, T., Hannappel, E., Nielsen, P.F., Maier, C., Maaßen, J., Landis, B., Przybylski, M. and Schäfer, K.P. (1992). Primary structure differences of human surfactant associated proteins isolated from normal and proteinosis lung surfactant. Biochem. Biophys. Acta 1138, 261. (original research article)

Van den Bremer, E.T.J., Keeble, A.H., Jiskoot, W., Spelbrink, R.E.J., Maier, C.S., van Hoek, A., Visser, A.J.W.G., James, R., Moore, G.R., Kleanthous, C. and Heck, A.J.R. (2004) Distinct conformational stability and functional activity of four highly homologous endonuclease colicins; Protein Science, 13, 1391-1401. (original research article)

Van den Bremer, E., Jiskoot, W., Kleanthous, C., Heck, A.J. and Maier, C.S.* (2002) Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray time-of-flight ionization mass spectrometry, Protein Science, 11, 1738-1752. (original research article)

Tahallah, N., van den Heuvel, R.H.H., van Berkel, W.J.H., Maier, C.S. and Heck, A.J.R. (2002) Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase, J. Biol. Chem., 277, 36425-36432. (original research article)

Tahallah, N., Pinkse, M., Maier, C.S. and Heck, A.J.R. (2001) The effect of the source pressure on the abundance of ions of noncovalent protein assemblies in an electrospray ionization orthogonal time-of-flight instrument. Rapid Commun. Mass Spectrom. 15, 596-601. (original research article)

Tahallah, N., Maier, C. S., Heck, A. J. R., van den Heuvel, R. H. H., van den Berg, W. A. M., van Berkel, Willem J. H. (2002) Cofactor-dependent assembly of the flavoprotein vanillylalcohol oxidase. Flavins and Flavoproteins 2002, Proceedings of the 14th International Symposium, Cambridge, U. K., 387-392.

Stevens, J.F. and Maier, C.S. (2008) Acrolein: Source, metabolism and biomolecular interactions relevant to human health; Molecular Nutrition and Food Research, 2, 7-25 (review; invited contribution).

Stevens, J. F. and Maier, C. S. (2011) Acrolein. Mol. Nutr. Food Res. 2011 Sep;55(9):1275-6. (Editorial in Mol. Nutr. Food Res. Sep;55(9): Special Issue on Acrolein)

Schäfer, A., Nielsen, P.F., Voss, T., Hannapppel, E., Maier, C., Maaßen, J., Sturm, E., Klemm, K., Schäfer, K.P., and Przybylski, M. (1990) Primary structure elucidation of human and bovine pulmonary surfactant SP-C proteins with covalent bis-cysteinyl4,5-thioesterpalmitate residues. In: Peptides. (Andreu, D. and Giralt, A., Eds.), Escom Science Publ., 350 (Book chapter)

Satyanarayana Gouthu, Jeff Morre, Claudia S. Maier and Laurent G. Deluc (2012). An analytical method to quantify three plant hormone-families in grape berry using liquid chromatography and multiple reaction monitoring mass spectrometry. Recent Advances in Phytochemistry.

Sasidhar Nirudodhi, Derek Parsonage, P. Andrew Karplus, Leslie B. Poole, and Claudia S. Maier* (2011) Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry. Int J Mass Spectrom. 302, 93-100 (original research article, invited contribution)

S. I. Wickramasekara, F. Zandkarimi, J. Morré, J. Kirkwood, L. Legette, Y. Jiang, A.F. Gombart, J. F. Stevens and C.S. Maier* (2013) Electrospray Quadrupole Travelling Wave Ion Mobility Time-of-Flight Mass Spectrometry for the Detection of Plasma Metabolome Changes Caused by Xanthohumol in Obese Zucker (fa/fa) Rats. Metabolites 3(3), 701-717 (invited contribution, original research article)

Rhoads, T.W., Lopez, N.I., Zollinger, D.R., Morre, J.T., Arbogast, B.L., Maier, C.S., Denoyer, L., Beckman, J.S. (2011) Measuring Copper and Zinc Superoxide Dismutase from Spinal Cord Tissue using Electrospray Mass Spectrometry. Anal. Biochem. Mar 28. (original research article)3

Przybylski, M., Maier, C., Hägele, K., Bauer, E., Hannappel, E., Nave, R., Krüger, U., and Schäfer, K.P. (1994). Primary structure elucidation, surfactant function and specific formation of supramolecular structures of lung surfactant-associated SP-C proteins. In Peptides - Chemistry, Structure and Biology (R.S. Hodges and J. A., Smith, Eds). Escom, Leiden, 338-340 (Book chapter)

Pinkse, M.W.H., Maier, C.S., Kim, J.-I., Oh, B.-H., and Heck , A.J.R. (2003) Macromolecular assembly of H. pylori urease investigated by mass spectrometry, J. Mass Spectrom., 38, 315-320. (original research article)

Miranda, C.L., Maier, C.S., Stevens, J.F. (2012) Flavonoids. eLS - citable reviews in the life sciences, Wiley. (electronic book chapter, invited contribution)

McNamara, M., Tzeng, S. C., Maier, C., Zhang, L., Bermudez, L. E. (2012) Surface Proteome of "Mycobacterium avium subsp. hominissuis" during the Early Stages of Macrophage Infection. Infect Immun. 2012 May; 80(5), 1868-80. (original research article)

Marley, K., Mooney, D.T., Clark-Scannell, G., Tong, T.-T., Watson, J., Hagen, T.M., Stevens, J.F., and Maier, C.S.* (2005) Mass tagging approach for mitochondrial thiol proteins. J. Proteome Res. 4, 1403-1412. (original research article)

Marley K., Maier C. S., Helfand S. C. (2012) Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma. Vet. Comp. Oncol. 10, 214-22 (original research article)

Maier, C.S., Schimerlik, M.I., and Deinzer, M.L. (1999). Thermal denaturation of Escherichia coli thioredoxin studied by hydrogen/deuterium exchange and electrospray ionization mass spectrometry: Monitoring a two-state protein unfolding transition. Biochemistry, 38, 1136-1143. (original research article)

Maier, C.S., Paša Tolic, L., Yan, X., Harder, M.E., Smith, R.D., Schimerlik, M.I. and Deinzer, M.L. (2000). Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of the recombinant human macrophage colony stimulating factor β. J. Am. Soc. Mass Spectrom., 11, 237-243. (original research article)

Maier, C.S., Kim, O.-H. and Deinzer, M.L. (1997). Conformational study of the A-state of cytochrome c by hydrogen/deuterium exchange monitored by electrospray mass spectrometry. Anal. Biochem., 252, 127-135. (original research article)

Maier, C.S., Arbogast, B., Hahn, U., Kuchumov, A.R., Vinogradov, S.N., Walz, D.A., and Deinzer, M.L. (1997). A mass spectrometric study of the molecular heterogeneity of the monomer subunit of Lumbricus terrestris hemoglobin. J. Am. Soc. Mass Spectrom., 8, 352-364. (original research article)

Maier, C.S. and Deinzer, M.L. (2005) Protein conformations, interactions and H/D exchange. Meth. Enzymol., 402, 312-360. (review, invited contribution)

LeeCole Legette, Ralph L. Reed, Lia Murty, Claudia S. Maier and Jan F. Stevens (201x) Application of Paper Strip Extraction in Combination with LC-MS/MS in Pharmacokinetics. Current Trends in Mass Spectrometry. in press (October issue) (invited contribution)

Kirkwood JS, Maier C, Stevens JF. (2013) Simultaneous, untargeted metabolic profiling of polar and non-polar metabolites by LC-Q-TOF mass spectrometry. Curr. Protol. Toxicol. Chapter 4:Unit4.39. (invited contribution).

Kim, M.-Y., Maier, C.S., Reed. D.J. and Deinzer, M.L. (2002) Conformational changes in chemically modified Escherichia coli thioredoxin monitored by H/D exchange and electrospray ionization mass spectrometry, Protein Science, 11, 1320-1329. (original research article)

Kim, M.-Y., Maier, C.S., Reed, D.J., Ho, P.S., and Deinzer, M.L. (2001) Intramolecular interactions in chemically modified thioredoxin monitored by hydrogen/deuterium exchange and electrospray ionization mass spectrometry; Biochemistry, 40, 14413-14421. (original research article)

Kim, M.-Y., Maier, C.S., Reed, D.J. and Deinzer, M.L. (2001) Site-specific amide hydrogen/deuterium exchange in E. coli thioredoxins measured by electrospray ionization mass spectrometry; J. Am. Chem. Soc., 123, 9860-9866. (original research article)

Juan D. Chavez, William H. Bisson, and Claudia S. Maier*(2010) A targeted mass spectrometry-based approach for the identification and characterization of proteins containing -aminoadipic and -glutamic semialdehyde residues. Anal. Bioanal. Chem. 398(7-8), 2905-14. (original research article)

Juan D. Chavez, Jianyong Wu, William Bisson, and Claudia S. Maier* (2011) Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction. Journal of Proteomics, 74, 2417-29 (original research article, invited contribution)

Juan Chavez, Woon-Gye Chung, Cristobal L. Miranda, Mudita Singhal, Jan F. Stevens and Claudia S. Maier* (2010) Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells. Protein carbonylation is diminished by ascorbic acid, Chem. Res. Toxicol. 23, 37-47.1 (original research article)

Jing Wang, Jie Zhang, Brian Arbogast and Claudia S. Maier* (2011) Tandem Mass Spectrometric Characterization of Thiol Peptides Modified by the Chemoselective Cationic Sulfhydryl Reagent (4-Iodobutyl)Triphenylphosphonium — Effects of a Cationic Thiol Derivatization on Peptide Fragmentation; J. Am. Soc. Mass Spectrom., 22:1771-83. (original research article)

Jianyong Wu, Jan F. Stevens and Claudia S. Maier* (2011) Mass Spectrometry-based quantitation of acrolein-modified Cys-containing peptides in an in vivo model of oxidative stress, Mol. Nutr. Food Res. Sep;55(9):1401-10 (original research article)

J. Lorang, T. Kidarsa, C.S. Bradford, B. Gilbert, M. Curtis, S. Tzeng, C.S. Maier, J. Wolpert (2012) Tricking the Guard: Exploiting Plant Defense for Disease Susceptibility, Science 338, 659-62. (original research article)

Ishmael*, J. E., Amparan, D., Safic, M., Vogel, W., Pham, T., Marley, K., Filtz, T. M. and Maier, C. S.* (2007) Nonmuscle myosins II-B and Va are components of detergent-resistant membrane skeletons derived from mouse forebrain, Brain Res., 1143:46-59. (original research article)

Heck, Albert J. R. and Maier, Claudia S.; (2002) Biomolecular mass spectrometry related to drug research. Pharmacochemistry Library, Vol. 32, 81-94 (book chapter)

Han, B., Stevens, J.F. and Maier, C.S.* (2007) Design, Synthesis and Application of a Hydrazide-functionalized Isotope-coded Affinity Tag (HICAT) for the Identification and Quantification of Oxylipid-Protein Conjugates; Anal. Chem. 79, 3342-3354. (original research article)

Han, B., Gross, H., McPhail, K.L., Goeger, D., Maier, C.S., Gerwick, W.H. (2011) Wewakamide A and Guineamide G, Cyclic Depsipeptides from the Marine Cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J. Microbiol. Biotechnol. 21:930-6.

Han, B., Goeger, D., Maier, C.S., and Gerwick, W.H.* (2005) The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J. Org. Chem. 70, 3133-3139. (original research article)

Han B, Hare M, Wickramasekara S, Fang Y, Maier CS.* (2012) A comparative 'bottom up' proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids. J Proteomics. 75, 5724-33. (original research article)

Gray, N., Morre, J., Kelley, J., Maier, C., Stevens F., Quinn J., Soumyanath A. Centella asiatica protects against the toxic effects of intracellular beta-amyloid accumulation. Planta Medica, 79(10), pg. 836, 2013 (Conference Proceedings, 2013 Annual meeting of the American Society of Pharmacognosy. Natural products at a crossroad: current and future directions. July 14-17, St Louis, Missouri, USA.)

Gouthu S, Skinkis PA, Morre J, Maier CS, Deluc LG. (2012) Berry nitrogen status altered by cover cropping: Effects on berry hormone dynamics, growth and amino acid composition of Pinot Noir. Food Chemistry, 135, 2012, 1-8. (original research article)

Gómez, L.A., Monette, J.S., Chavez, J.D., Maier. C.S. and Hagen T.M. (2009) Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. Arch. Biochem. Biophys., 490, 30-35.3 (original research article)

Forsberg N.D., Rodriguez-Proteau R, Ma L., Morré J., Christensen J.M., Maier C.S., Jenkins J.J., Anderson K.A. (2011) Organophosphorus pesticide degradation product in vitro metabolic stability and time-course uptake and elimination in rats following oral and intravenous dosing. Xenobiotica, 41, 422-9. (original research article)

Dreher, T.W., Brown, N, Bozarth, C.S., Schwartz, A.D., Riscoe, E., Thrash, C., Bennett, S.E., Tzeng, S.C., and Maier C.S. (2011) A freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages. Environ. Microbiol. 2011, 13, 1858-74 (original research article)3

De Mol, N.J., Catalina, M.I., Fischer, M.J.E., Broutin, I., Maier, C.S. and Heck A.J.R. (2004). Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. Biochim. Biophys. Acta 1700, 53–64. (original research article)

Claudia S. Maier*, Juan Chavez, Jing Wang, Jianyong Wu (2010) Peptide adducts of aldehydic lipid peroxidation products: Identification and characterization of protein adducts using an aldehyde /keto reactive probe in combination with mass spectrometry. Meth. Enzymol., 473, 305-330 (review, invited contribution)

Chung, W.-G., Miranda, C.L., Stevens, J.F. and Maier, C.S.* (2009) Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species; Food Chem. Toxicol. 47, 827-36. (original research article)

Chung, W.-G., Miranda, C.L. and Maier, C.S.* (2008) Detection of carbonyl-modified proteins in interfibrillar rat mitochondria using N'-aminooxymethylcarbonylhydrazino-D-biotin as an aldehyde/keto-reactive probe in combination with Western blot analysis and tandem mass spectrometry; Electrophoresis, 29, 1317-1324. (original research article)

Chung, W.-G., Miranda, C.L. and Maier, C.S.* (2007) Epigallocatechin gallate (EGCG) potentiates the cytotoxicity of rotenone in neuroblastoma SH-SY5Y Cells; Brain Res., 1176, 133-142. (original research article)

Chung, W.-G. and Maier*, C.S. (2008) ‘Mass Spectrometry-based Identification and Characterization of Oxylipid-Protein Conjugates’ (Unit 17.9) in “Current Protocols in Toxicology” (invited contribution).

Chavez, J., Wu, J., Han, B., Chung, W.-G., and Maier, C.S.* (2006) New Role for an Old Probe: Affinity Labeling of Oxylipid Protein Conjugates by N’-Aminooxymethyl-carbonylhydrazino D-biotin. Anal. Chem. 78, 6847-6854. (original research article)

Catalina, M.I., Dekker, F.J., Liskamp, R.M.J., Versluis, C., Maier, C.S., and Heck, A.J.R. (2003) Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase, Int. J. Mass Spectrom., 228, 879-890. (original research article)

Bossi, R.T., Aliverti, A., Zanetti, G., Ferrari, D., Tahallah, N., Maier, C.S., Heck, A.J.R., Rizzi, M., and Mattevi, A. (2002) An unprecedented covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase, Biochemistry, 41, 8807-8818. (original research article)

A.J.R. Heck and C.S. Maier (2002) Biomolecular mass spectrometry related to drug research" in Trends in Drug Research III; Proceedings of 13th Noordwijkerhout-Camerino Symposium; Ed. H. van der Goot, p. 81-94.

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