Assistant ProfessorSandra Loesgen
Gilbert 333
Terence Bradshaw Scholar

Ph.D. Chemistry, Georg-August University of Gottingen, Germany 2007
Postdoctoral Fellow, Scripps Institution of Oceanography, University of California - San Diego 2008-2010
Postdoctoral Fellow, NIH Intramural Research, NIDDK, Bethesda, MD 2011-2013

German Research Foundation (DFG) Fellowship 2008-2010
National Institutes of Health (NIH) Intramural Research Trainee Award 2011-2013
NIH & FDA Thermo Fisher 'Glycobiology of Viruses' Best Poster Award, Bethesda, MD 2012
Terence Bradshaw Scholar 2013

Adjunct Faculty in Pharmaceutical Sciences

Research Group Website

Organic and Bioorganic Website

Research Interests:
My laboratory is principally interested in target-based drug discovery with a focus on (1) identification of genetically encoded, biologically active natural products from microbial sources, (2) developing new screening techniques for small molecules and proteins that inhibit viral cell entry, and (3) using integrated approaches to elucidate the molecular basis of inhibitor interactions with target viral proteins by means of biophysical and structural studies.

Representative Publications (selected):

  • D.A. Adpressa, S. Loesgen, Chem. Biodivers. 2016, 13, 253-259. DOI: 10.1002/cbdv.201500310
  • S. Maier, T. Pflüger, S. Loesgen, K. Asmus, E. Brötz, T. Paululat, A. Zeeck, S. Andrade, A. Bechthold: Novel insights into the bioactivity and epoxide formation in mensacarcin by MsnO8. ChemBioChem 2014, 15, 749-756.
  • A. Kachko*, S. Loesgen*, S. Shahzad-ul-Hussan, W. Tan, I. Zubkova, K. Takeda, F. Wells, S. Rubin, C. A. Bewley and M. E. Major: Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: mechanistic differences between the high- mannose specific lectins MVL, CV-N, and GNA. Mol. Pharmaceutics 2013, 10-23-2013 DOI: 10.1021/mp400399b.
  • M. Pancera, S. Shahzad-ul-Hussan, N. A. Doria-Rose, K. Dai, J. S. McLellan, R. P. Staupe, Y. Yang, B. Zhang, S. Loesgen, M. N. Amin, L.-X. Wang, D. R. Burton, W. C. Koff, G. J. Nabel, J. R. Mascola, C. A. Bewley, P. D. Kwong: Structure of broadly neutralizing antibody PG16 in complex with HIV-1 gp120 V1/V2 domain reveals complex-type N-glycan recognition. Nat. Struct. Mol. Biol. 2013, 20, 804-813.
  • N. M. Haste, W. Thienphrapa, D. N. Tran, S. Loesgen, P. Sun, S.-J. Nam, P. R. Jensen, W. Fenical, G. Sakoulas, V. Nizet, M. E. Hensler: Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J. Antibiot. 2012, 65, 593–598.
  • L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J. G. Ruby, P. Skewes-Cox, W. Fenical, B. S. Moore: Merochlorins A–D, cyclic meroterpenoid antibiotics biosynthesized from divergent pathways involving vanadium-dependent chloroperoxidases. J. Am. Chem. 2012, 134, 11988-11991.
  • G. Sakoulas, S.-J. Nam, S. Loesgen, W. Fenical, P. R. Jensen, V. Nizet, M. Hensler: Novel Bacterial Metabolite Merochlorin A Demonstrates in vitro Activity against Multi-Drug Resistant Methicillin-Resistant Staphylococcus aureus. PLoS ONE 7(1): e29439. 2012. doi:10.1371/journal.pone.0029439
  • A. Edlund, S. Loesgen, W. Fenical, P. R. Jensen: Geographic Distribution of Secondary Metabolite Genes in the Marine Actinomycete Salinispora arenicola. Appl. Environ. Microbiol. 2011, 77, 5916-5925.
  • S. Loesgen, T. Bruhn, K. Meindl, I. Dix, B. Schulz, A. Zeeck, G. Bringmann: (+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics. Eur. J. Org. Chem. 2011, 26, 5156-5162.
  • B. Schulz, S. Draeger, T. E. dela Cruz, J. Rheinheimer, K. Siems, S. Loesgen, J. Bitzer, O. Schloerke, A. Zeeck, I. Kock, H. Hussein, J. Dai, K. Krohn: Screening strategies for obtaining novel, biologically active, fungal secondary metabolites from marine habitats. Botanica Marina 2008, 51, 219-234.
  • S. Lösgen, J. Magull, B. Schulz, S. Draeger, A. Zeeck: Isofusidienols, Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp. Eur. J. Org. Chem. 2008, 698-703.
  • S. Lösgen, O. Schlörke, K. Meindl, R. Herbst-Irmer, A. Zeeck: Structure and Biosynthesis of Chaetocyclinones, New Polyketides Produced by an Endosymbiotic Fungus. Eur. J. Org. Chem. 2007, 2191-2196.