Vicki and Patrick F. Stone Scholar
B. S. (2000) University of Wisconsin;
Ph.D. (2005) University of California - Berkeley;
Postdoctoral Fellow (2006 - 2009) University of California - Irvine
Research Group Website: http://chemistry.oregonstate.edu/beaudry/
The rich structural diversity, intriguing molecular architectures, and potent biological activities of natural products make these compounds compelling targets for synthesis. However, chemists remain limited by the available methods for the efficient construction of many structural motifs.
Research in my group is directed at developing new methods to address these limitations. The approach seeks to conceptualize the most strategically powerful simplification of the target, giving rise to readily available starting materials. This simplification will often demand methodology which does not currently exist, but would have widespread application. Once developed, we will use these methods for the synthesis of a variety of complex natural products. Specific areas of interest include nitrogen-rich alkaloids, enantioselective catalysis, chirality of organic molecules, cascade processes, radical reactions, and organometallic chemistry.
"Chirality in Diarylether Heptanoids: Synthesis of Myricatomentogenin, Jugcathanin, and Congeners." Salih, M. Q.; Beaudry, C. M. Org. Lett. 2012, ASAP.
"High-Yielding Oxidation of beta-Hydroxyketones to beta-Diketones Using o-Iodoxybenzoic Acid." Bartlett, S. L.; Beaudry, C. M. J. Org. Chem. 2011, 76, 9852-9855.
"Divergent Synthesis and Chemical Reactivity of Bicyclic Lactone Fragments of Complex Rearranged Spongian Diterpenes." Schnermann, M. J.; Beaudry, C. M.; Genung, N. E.; Canham, S. M.; Unteidt, N. L; Karanikolas, B. D. W.; Sutterlin, C.; Overman, L. E. J. Am. Chem. Soc. 2011, 133, 17494-17503.
"Total Synthesis of (-)-SNF4435 C and (+)-SNF4435 D." Beaudry, C.M.; Trauner D. Org. Lett. 2005, 7, 4475-4477.
"Desymmetrization by Ring-Closing Metathesis Leading to 6,8-Dioxabicyclo[3.2.1]octanes: A New Route of the Synthesis of (+)-exo- and endo- Brevicomin." Burke, S.D.; Muller, N.; Beaudry, C.M. Org. Lett. 1999, 1, 1827-1829.