| Chris Beaudry |
Organic Chemistry |
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Assistant Professor
Education: B. S. University of Wisconsin (2000); Ph.D. University
of California - Berkeley (2005); Postdoctoral Fellow, University
of California - Irvine (2006 - 2009).
Awards: Hilldale Research Fellow (1999); Abbott Laboratories
Research Fellow (2001); Tularik Scholar -Center for New Directions
in Organic Synthesis (2002); BMS Predoctoral Fellowship (2003);
UC Berkeley Outstanding Graduate Student Instructor Award (2004);
Roche Pharmaceuticals Predoctoral Fellowship (2005); National
Institutes of Health Postdoctoral Fellow (2006-2009).
Email: christopher.beaudry@oregonstate.edu
Office: Gilbert 333
Phone: 541-737-6746
FAX: 541-737-2062
Organic and Bioorganic Website:
http://www.chemistry.oregonstate.edu/organic/
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Research Interests
The rich structural diversity, intriguing molecular architectures, and potent biological activities of natural products make these compounds compelling targets for synthesis. However, chemists remain limited by the available methods for the efficient construction of many structural motifs.
Research in my group is directed at developing new methods to address these limitations. The approach seeks to conceptualize the most strategically powerful simplification of the target, giving rise to readily available starting materials. This simplification will often demand methodology which does not currently exist, but would have widespread application. Once developed, we will use these methods for the synthesis of a variety of complex natural products. Specific areas of interest include nitrogen-rich alkaloids, enantioselective catalysis, chirality of organic molecules, cascade processes, radical reactions, and organometallic chemistry.
Representative Publications
- Photochemical origin of the immunosuppressive SNF4435C/D and formation of orinocin through ‘Polyene splicing’. C. Angew. Chem. Int. Ed. 2006, 45 (46), 7835 - 7838.
- Total Synthesis of (–)-SNF4435 C and (+)-SNF4435 D. Org. Lett. 2005, 7 (20), 4475-4477.
- Dienophile Twisting and Substituent Effects Influence Reaction Rates of Intramolecular Diels-Alder Cycloadditions: A DFT Study. J. Am. Chem. Soc. 2005, 127 (11), 3688- 3689
- Intramolecular Diels-Alder Reactions of 5-Vinyl-1,3-cyclohexadienes. Org. Lett. 2003, 5 (10), 1701-1704.
- Synthetic Studies Toward SNF4435 C and SNF4435 D. Org. Lett. 1999, 4 (13), 2221 - 2224
- Desymmetrization by Ring-Closing Metathesis Leading to 6,8-Dioxabicyclo[3.2.1]octanes: A New Route for the Synthesis of (+)-exo- and endo-Brevicomin. Org. Lett. 1999, 1 (11), 1827-1829.
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